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TYRPHOSTIN B44

Product Name
TYRPHOSTIN B44
CAS No.
133550-32-0
Chemical Name
TYRPHOSTIN B44
Synonyms
AG 527;Zinc03871437;TYRPHOSTIN B44;TRYPHOSTIN AG 527;TYRPHOSTIN B44(-);TYRPHOSTIN AG 527;Reaxys ID: 4356230;ALPHA-CYANO-(-)-(R)-N-(ALPHA-PHENETHYL)-3,4-DIHYDROXYCINNAMIDE;(-)-(r)-n-(α-methylbenzyl)-3,4-dihydroxybenzylidenecyanoacetamide;(-)-(R)-N-(ALPHA-METHYLBENZYL)-3,4-DIHYDROXYBENZYLIDINECYANOACETAMIDE
CBNumber
CB8197102
Molecular Formula
C18H16N2O3
Formula Weight
308.33
MOL File
133550-32-0.mol
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TYRPHOSTIN B44 Property

Boiling point:
603.0±55.0 °C(Predicted)
Density 
1.299±0.06 g/cm3(Predicted)
storage temp. 
−20°C
solubility 
DMSO or ethanol: soluble
form 
Yellow solid.
pka
8.81±0.10(Predicted)
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
T947983
Product name
TyrphostinB44,(-)enantiomer
Packaging
5mg
Price
$40
Updated
2021/12/16
TRC
Product number
T947983
Product name
TyrphostinB44,(-)enantiomer
Packaging
50mg
Price
$255
Updated
2021/12/16
Usbiological
Product number
256987
Product name
Tyrphostin B44,
Packaging
10mg
Price
$366
Updated
2021/12/16
Usbiological
Product number
256986
Product name
Tyrphostin B44,
Packaging
10mg
Price
$366
Updated
2021/12/16
TRC
Product number
T947983
Product name
TyrphostinB44,(-)enantiomer
Packaging
100mg
Price
$475
Updated
2021/12/16
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TYRPHOSTIN B44 Chemical Properties,Usage,Production

Uses

Tyrphostin B44, (-) enantiomer is a potent inhibitor of (EGFR) kinase.

Biological Activity

Potent inhibitor of epidermal growth factor receptor (EGFR) kinase (IC 50 = 0.4 μ M), more active than the (+) enantiomer ((S)-(E)-2-Cyano-3-(3',4'-dihydroxyphenyl)-N-(1-phenylethyl)-2-propenamide ). Selective over ErbB2.

TYRPHOSTIN B44 Preparation Products And Raw materials

Raw materials

Preparation Products

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TYRPHOSTIN B44 Suppliers

China 12 Europe 1 Germany 3 Switzerland 3 United Kingdom 5 United States 11 Global 35

133550-32-0, TYRPHOSTIN B44Related Search:

TYRPHOSTIN B44, (+) ENANTIOMER N1-ISOPROPYL-2-CYANOACETAMIDE D,L-N-(ALPHA-PHENYLETHYL) METHACRYLAMIDE AG 99 3-(1-PHENYLETHYLAMINO)PROPANENITRILE TYRPHOSTIN B44 (R)-(+)-N-ALLYL-ALPHA-METHYLBENZYLAMINE& N-ISOPROPYLMETHACRYLAMIDE AG 490 BENZYL-((E)-3-PHENYL-ALLYL)-AMINE

  • (R)-(E)-2-CYANO-3-(3',4'-DIHYDROXYPHENYL)-N-(1-PHENYLETHYL)-2-PROPENAMIDE
  • (-)-(R)-N-(ALPHA-METHYLBENZYL)-3,4-DIHYDROXY-BENZYLIDENECYANOACETAMIDE
  • (-)-(R)-N-(ALPHA-METHYLBENZYL)-3,4-DIHYDROXYBENZYLIDINECYANOACETAMIDE
  • TYRPHOSTIN AG 527
  • TYRPHOSTIN B44
  • TYRPHOSTIN B44(-)
  • TRYPHOSTIN AG 527
  • (E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-[(1R)-1-phenylethyl]-2-propenamide
  • AG 527
  • ALPHA-CYANO-(-)-(R)-N-(ALPHA-PHENETHYL)-3,4-DIHYDROXYCINNAMIDE
  • (-)-(r)-n-(α-methylbenzyl)-3,4-dihydroxybenzylidenecyanoacetamide
  • Tyrphostin B44, (-)-(R)-N-(α-Methylbenzyl)-3,4-dihydroxybenzylidenecyanoacetamide
  • Zinc03871437
  • Reaxys ID: 4356230
  • 2-Propenamide, 2-cyano-3-(3,4-dihydroxyphenyl)-N-[(1R)-1-phenylethyl]-, (2E)-
  • 133550-32-0
  • BioChemical
  • Cell Signaling and Neuroscience
  • Cell Biology
  • Receptor Tyrosine Kinase Inhibitors
  • Epidermal Growth Factor Receptor (EGFR)
  • Kinase/Phosphatase Biology
  • Intracellular Signaling
  • Protein Kinase